Differential Roles of Stromal Celis , Interleukin - 7 , and kit - Ligand in the Regulation of B

Newly formed B lymphocytes are a population of rapidly renewed cells id the bone marrow of mammals and their steady stat? production presumably depends on a cascade of regulatory cells and cytokines. Although Considerable information had b&&n forthcoming about the role of interleukin-7 (IL-7) in potentiating pre-B-cell proliferation, few studies have addressed the possibility that multiple cytokines are involved in the progression of early events in cellular differentiation and proliferation in this hematopoietic lineage. Our laboratory previously described pre-B-cell differentiation mediated by the bone marrow stromal cell line S17. In this study, we further delineate the role of stromal cells in differentiation and proliferation of pre-B cells. These experi-